Contrary to generally accepted belief, a recent review and analysis of published studies did not reveal a consistent association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen and exacerbation of Crohn’s disease and ulcerative colitis. Nevertheless, when the analysis was limited to studies with a low risk of bias, three was a link between NSAIDs use and exacerbation of Crohn’s disease but not ulcerative colitis.
The Alimentary Pharmacology & Therapeutics analysis included 18 studies published between 1983 and 2016.
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