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A biomarker for diagnosing celiac disease in people on a gluten-free diet

Celiac disease is a complex condition, routinely treated by means of a strict gluten-free diet. One of the diagnostic challenges of this disease is that patients need to be consuming gluten so that a correct diagnosis by means of endoscopy can be made. Yet nowadays there are more and more people who opt to eliminate gluten from their diets before seeing a specialist, and this makes it tremendously difficult to reliably diagnose the disease. However, as José Ramón Bilbao and Nora Fernandez-Jimenez, researchers at the UPV/EHU and the Biocruces-Bizkaia Institute of Healthcare Research, pointed out, “the self-diagnosis of gluten intolerance is a growing global phenomenon as it reaches 12-13 % of the general population in European countries such as Italy and the United Kingdom”.

In an article published recently in the Human Molecular Genetics journal these researchers report on the discovery of a biomarker that could enable celiac disease to be diagnosed in the blood of people on a gluten-free diet. In this work, through an analysis of applied statistics, the researchers have discovered that the relative expression of the isoforms of the UBE2L3 gene in the blood makes it possible to distinguish with 100% sensitivity and specificity celiac patients on a gluten-free diet.

From basic research to clinical practice

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